1. Introduction. – 2. Methods and Materials. – 3. Overview of the new Decree on personal data protection in Vietnam and the EU’s General Data Protection Regulation 2016/679. – 3.1. Key takeaways from Vietnam's Personal Data Protection Decree 2023. – 3.2. Overview of the EU's General Data Protection Regulation (GDPR) 2016/679. – 4. Potential conflicts between two legal instruments in practical implementation. – 5. Conclusions.